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          a healthier & more sustainable future.

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        Featured News

                Our 2024 Impact Report

                  highlights the incredible work our portfolio companies are doing to improve the health of people & planet

                September 17, 2024

                —

                Wireframe

                LevelTen Energy

                  lands $65M from investors including Microsoft & Google to expand clean energy marketplace services

                July 16, 2024

                —

                MSN

                Xcimer Energy

                  raises $100M Series A to build laser-driven nuclear fusion prototype system

                June 4, 2024

                —

                Axios

                Mammoth Bio

                  announces a milestone $100M+ partnership with Regeneron to develop in-vivo CRISPR-based gene editing therapies

                April 25, 2024

                —

                Regeneron

                CNBC

                  interviewed our co-founder Paul Straub on how Recurrent is transforming the used EV market

                March 25, 2024

                —

                CNBC

                Xcimer Energy

                  wins exclusive US Department of Energy award to further develop their nuclear fusion technology

                May 31, 2023

                —

                US DOE

                Enveda Biosciences

                  announces oversubscribed financing, bringing total Series B round to US$119 Million

                April 20, 2023

                —

                BusinessWire

                Full Harvest

                  founder Christine Moseley in Newsweek feature on women entrepreneurs creating new businesses in record numbers

                March 15, 2023

                —

                Newsweek

                LevelTen Energy

                  partners with Google to help all organizations accelerate their journey to 24/7 carbon-free energy

                March 15, 2023

                —

                Google

                Think Bioscience

                  raises $17M oversubscribed seed round to develop small molecule drugs that hit un-druggable proteins

                August 19, 2022

                —

                Innosphere

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            Read our 2024 Impact Report

                              We help founders who

                                  harness biology to

                                  engineer better products

                                  .

                            Investing in technology for people & planet

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                              We help founders who

                                  create scalable solutions to

                                  climate change

                                  .

                            Investing in technology for people & planet

                              We help founders who

                                  deploy AI & automation to

                                  empower us

                                  .

                            Investing in technology for people & planet

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                              We help founders who

                                  deliver healthcare that's

                                  personal & proactive

                                  .

                            Investing in technology for people & planet

                                      Because they are cool
                                    and helpful

                              We help founders who

                                  transport us safely, with

                                  zero carbon footprint

                                  .

                            Investing in technology for people & planet

                                      Because they are cool
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        Our Purpose.

        We invest capital, time & belief to accelerate your success.

          Every startup journey is unique - there's no single playbook that works for everyone, especially in the early days. We try to meet you where you are and help you get where you dream of going. We listen with empathy, we tell you the truth and we'll dive in to contribute hands-on support whenever you need it. You should expect nothing less from any investor.
                We invest in driven founders who can build pioneering companies that improve our world.
                Our Focus
                We partner closely with our founders from the beginning, and we're on call when they need us most.
                Our Approach

            Harsh was the first VC we met who immediately understood our potential, and he's been a trusted mentor to me since our seed round. His empathy & experience building companies in our space make him an ideal investor for any 1st-time founder."

              Trevor Martin

                Co-founder & CEO, Mammoth Biosciences
              "

            Wireframe led our seed round and they’ve been invaluable to me as a solo founder. I’ve been able to rely on Paul as a true partner. We have an open, trusted relationship that goes well beyond what most founders might expect from their investors."

              Arch Rao

                Founder & CEO, SPAN
              "

            Wireframe’s expertise in the EV & energy markets made them the perfect lead VC for our seed round. Paul & Harsh are great partners, striking the right balance between strategic guidance & support while giving us flexibility to execute our vision."

              Muffi Ghadiali

                Founder & CEO, Electriphi
              "

            Before we ever raised capital, Harsh introduced us to our lead scientific advisor & spent hours with us on a whiteboard helping to hone our thinking. The Wireframe team were great partners at GeneWEAVE and we're excited to work with them again."

              Diego Rey

                Co-founder & CSO, Endpoint Health
              "

            Harsh is a great partner, in both good & tough times. He’s always available to help and pushes us to a high standard. And we'll forever appreciate his clarity & conviction to go all-in on Airflow, a decision that changed the course of our company."

              Ry Walker

                Founder, Astronomer
              "

            Wireframe's value to MycoWorks far exceeds the size of their check. This is the second time I've worked with Paul. He's always available, responsive and thoughtful. I trust his input and contribution as a true partner in building my business."

              Matt Scullin

                CEO, Mycoworks
              "

            Harsh brings a lifetime of wisdom coupled with uncanny insight, empathy, and authentic conviction to his investments. He is single-handedly the 'accelerator' you wished existed. He'll be the first person I call when I start my next company."

              Viswa Colluru

                Founder & CEO, Enveda Biosciences
              "

            Paul led our seed round and has been with me for the 7+ years since, through all of the highs and lows. There's no better partner I can imagine. Many investors say they are founder first - Paul's the real deal."

              Andy Ruben

                Founder & CEO, Trove
              "

            Wireframe was among the first funds to believe in us, and Paul and Harsh have been the most reliable, empathetic partners ever since. Whether supporting & advising us day-to-day or navigating a global crisis, I knew I could always lean on them."

              Rema Matevosyan

                Co-founder & CEO, Near Space Labs
              "

            I've worked with Harsh over 13 years as an investor in 2 of my companies. I’ve relied on his honesty and perspective on company-building time & time again. Having met hundreds of investors, he is easily in my top 5 of all time."

              Tim Enwall

                CEO, Misty Robotics
              "
        Our Portfolio.
          View all

        Our founders are on a mission to build a better future.

                  Product.
                  Purpose.
                  People.
                Product.
                Purpose.
                People.
              Product.
              Purpose.
              People.
                People.
                  People.
                Purpose.
                  Purpose.
                Product.
                  Product.
                  People.
                  Product.
                  Purpose.
                People.
                Product.
                Purpose.
              People.
              Product.
              Purpose.
                Product.
                  Product.
                People.
                  People.
                Purpose.
                  Purpose.
                  Purpose.
                  People.
                  Product.
                Purpose.
                People.
                Product.
              Purpose.
              People.
              Product.
                Purpose.
                  Purpose.
                Product.
                  Product.
                People.
                  People.

                Bioscience

              Improving human health with new diagnostics & therapeutics built with CRISPR

              Mammoth Biosciences

                  Seed
                  —
                  January 2018
                Discovering & commercializing novel CRISPR systems that enable new possibilities for expanding biology
                  View site →

              Retail

              Powering a new circular economy for the world's best retail brands

              Trove

                  Seed
                  —
                  May 2013
                Driven by a belief that sustainability is the only way forward for retail, helping brands succeed & the world thrive
                  View site →

              Energy

              The new interface for home energy

              SPAN.io

                  Seed
                  —
                  December 2018
                Making home energy connected & intuitive with a smart electrical panel that makes it easier to adopt clean energy
                  View site →

              Enterprise

              Empowering organizations to solve their most challenging problems

              Palantir

                  Series A
                  —
                  October 2005
                Software empowering organizations with the insights they need to solve complex, mission-critical problems (NYSE: PLTR)
                  View site →

              Agriculture

              Solving food waste at the farm level

              Full Harvest

                  Seed
                  —
                  October 2016
                Optimizing the agricultural supply chain with a business marketplace for imperfect & surplus produce
                  View site →

              Retail

              A new class of material, sustainably crafted from nature

              Mycoworks

                  Series A
                  —
                  May 2019
                Bioengineering a sustainable, high-performance & animal-free alternative to leather using fine mycelium
                  View site →

              Bioscience

              Applying AI to engineer next-generation cancer therapies

              Reverie Labs

                  Seed
                  —
                  March 2018
                Solutions for the most difficult, multi-objective medicinal chemistry problems to fill pressing medical needs
                  View site →

              Financial Services

              Believing in the power of values-based investing

              OpenInvest

                  Seed
                  —
                  May 2017
                Making it simple, and profitable, to align your investments with your values (acq. by JPMorgan, NYSE: JPM)
                  View site →

              Energy

              Simplifying renewable energy procurement for any corporation

              LevelTen Energy

                  Series A
                  —
                  September 2017
                The industry's leading platform for corporate energy buyers to find the right renewable energy solutions
                  View site →
        Our Team.
          Meet the team

        Meet our founders.

                  Harsh Patel

                      * Co-Founder
                      * Managing Director
                    * 

                  Paul Straub

                      * Co-Founder
                      * Managing Director
                    * 

          Committed to your success.

          We started Wireframe to serve founders solving some of the world's most important challenges. Over the years as investors & operators, we've built networks and domain expertise across themes we care deeply about. And we've been fortunate to work closely with founders from inception to success. As 1st check investors, we are completely aligned with you from the start.
          ‍

            View openings
        Our Community.

        Climb together.

        We're building a community where founders can share hard-earned lessons with their peers and pay it forward to the next generation when they succeed.

        Highlights from our community.

          Read about the latest news, interviews, and events happening across our community.
        View all
                Apr 23, 2025
                —
                Wireframe

            SF Climate Week 2025

              - key insights from our expert panel on how technology can help engineer global resilience
                      Blog
                Sep 17, 2024
                —
                Wireframe

            Our 2024 Impact Report

              highlights the incredible work our portfolio companies are doing to improve the health of people & planet
                      News
                May 21, 2024
                —
                Wireframe

            Cocoon Carbon

              is on a mission to remove millions of tonnes of CO2 and waste from heavy industry each year
                      Why we invested
                Apr 25, 2024
                —
                Regeneron

            Mammoth Bio

              announces a milestone $100M+ partnership with Regeneron to develop in-vivo CRISPR-based gene editing therapies
                      News
                Apr 20, 2023
                —
                BusinessWire

            Enveda Biosciences

              announces oversubscribed financing, bringing total Series B round to US$119 Million
                      News
                Apr 7, 2022
                —
                Wireframe

            Wireframe

              announces Wireframe II, a $77M fund to back founders on a mission to improve the health of people & planet
                      Blog

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